BOONTON, N.J., Sept. 20, 2012-- Unigene Laboratories, Inc. (OTCBB: UGNE), a leader in the design, delivery, manufacture and development of peptide-based therapeutics, today announced that its Chief Scientific Officer, Nozer Mehta, Ph.D., will present an update on UGP281, Unigene's novel anorexigenic peptide, at the 2012 Obesity Society's Annual Scientific Meeting in San Antonio.
Dr. Mehta's presentation, Recombinant Production, Oral Delivery and Preclinical Data on a Novel Anorexigenic Peptide UGP281, will be given on September 20, 2012 at 1:45 p.m. CT(2:45 p.m. ET) and will provide an overview of Unigene's peptide analog, UGP281, in development for the treatment of morbid obesity. The presentation will be part of a larger forum, entitled Pharmacologic and Device Session for Up and Coming Obesity Treatments.
In addition to Dr. Mehta's oral lecture, Unigene will present a poster at the conference describing in greater detail its pre-clinical studies of UGP281.
"With the incidence of obesity and its associated co-morbidities such as type 2 diabetes quickly on the rise, there is a significant opportunity to leverage oral peptide technologies in helping address these issues," said Dr. Mehta. "We are very encouraged by the promising preclinical data for UGP281 and believe it could offer a new, potentially high-value therapeutic for addressing morbid obesity."
UGP281, a potent anorexigenic peptide selectively targeting the amylin receptor, is under development by Unigene for the treatment of morbid obesity. In multiple-dose pharmacology studies in animal models, UGP281, administered subcutaneously, produced an acute and dramatic reduction in food intake, and a sustained, dose-related decrease in body weight of 10-15%. These effects were achieved at relatively low doses, and were consistent with the targeted pharmacology.
The efficacy of UGP281 was also demonstrated following oral delivery with Unigene's Peptelligence technology. UGP281 was well tolerated with no significant adverse findings in the studies conducted to date, and its therapeutic window appeared to be substantial.
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