DEERFIELD, Ill., Sept. 6, 2012 -- Results of a 10-week, phase 3 study published online in the American Journal of Medicine found the clinic systolic blood pressure (SBP) reductions of a fixed-dose combination of azilsartan medoxomil and chlorthalidone were significantly greater at six and ten weeks than those of azilsartan medoxomil co-administered with hydrochlorothiazide. Data also showed that more patients achieved their target blood pressure levels at the end of six and 10 weeks (secondary endpoints) when taking the azilsartan medoxomil and chlorthalidone fixed-dose combination.
"Hypertension management can be complex, and the use of combination therapy with a diuretic is a common treatment approach," said study co-author William C. Cushman, M.D., professor of preventive medicine at the University of TennesseeCollege of Medicine in Memphis, Tenn. "While hydrochlorothiazide is more commonly used in clinical practice, this study provides further support for the use of chlorthalidone in fixed-dose combination for patients with hypertension."
